Zangrado® & Progrado® –  Patented, Highly Concentrated Substances: 
(Support studies listed in the Scientific Studies section) 

Progrado® and Zangrado® are patented extracts derived from the viscous red latex of the Croton species tree found primarily in the South American rainforests and is sustainably wild-crafted. RNI original research demonstrated their mechanism of action as regulating the sensory afferent neurons that line the internal organs as well as the skin

Both extracts affect over-stimulated sensory neurons and signal the central nervous system to respond. Orally, both Progrado and Zangrado have been effective in the treatment of nausea and ulcers with implications for irritable bowel syndrome and gastroesophageal reflux disease as well as other gastrointestinal complaints. Topically, Zangrado has been shown clinically effective in reducing pain and itching associated with insect bites and stings, contact dermatitis, and plays a cicatrizing role in the healing process.

Sensory (afferent) neurons are nerves that respond to sensation – such as pain and itch – and are located throughout the body – lining the skin, organs and lungs.  In a sense, coughing is your body’s way of “itching” its lungs.

 Additionally, in human cells, Progrado has been shown to regulate overactive matrix metalloproteinases, molecular “scissors” from breaking down cartilage while increasing cellular IGF-1 levels.  

Zangrado® has been used in clinical trials topically to treat the pain and itch associated with bug bites and bee stings. It has been used internally to reduce nausea (emesis), diarrhea and also itch. Coughing is a method the lungs use to “itch” themselves so intuitively, Zangrado® would be effective internally for certain respiratory conditions. Progrado® has been shown to affect matrix metalloproteinase (MMPs). These are the molecular “scissors” that breakdown cartilage which is normally replaced by new cell Progrado® thus allows the body to repair itself.

Importantly, as with red wine, the proanthocyanidins found in Progrado® may offer benefits to the cardiovascular system.

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  3. Hunter P. The inflammation theory of disease: The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO Reports. 2012. 13(11):968-970.

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  5. Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Complement Altern Med. 2007. 7:34.

  6. Miller M, Ahmed S, Bobrowski P et al: Suppression of Human Cartilage Degradation and Chondrocyte Activation by a Unique Mineral Supplement (SierraSil™) and a Cat’s Claw Extract, Vincaria®. JANA, 2004, 7(2): 32-39.

  7. Miller M, Angeles F, Reuter B et al: Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis. BMC Complement Altern Med. 2001. 1:11.

  8. Miller M, Mehta K, Kunte S et al: Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond). 2005. 2:11.

  9. Miller M, Ahmed S, Bobrowski P et al: The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006. 6:13.

  10. Monaco C, Andreakos E, Kiriakidis S et al: Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci U S A. 2004. 13;101(15):5634-9.

  11. Piscoya J, Rodriguez Z, Bustamante S et al: Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001.50(9):442-8.

  12. Sandoval M, Okuhama NN, Zhang XJ et al: Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002. 9(4):325-37.

  13. Urdanibia I, Michelangeli F, Ruiz MC et al: Anti-inflammatory and antitumoural effects of Uncaria guianensis bark. J Ethnopharmacol. 2013. 150(3):1154-62.