Primary Functions:

  • Bioavailability

Piperine is the alkaloid responsible for the pungency, the heat found in Long Peppers (Piper longum) as well as black pepper. In a high dose, it is a powerful anti-inflammatory and acting by a mechanism similar to capsaicin, effective in arthritis. Additionally, there is evidence that it may act as an anti-depressant and increase cognitive function.

However, in Phytozon®, Piperine is incorporated in a low dose format specifically corresponding to the amount required to increase bioavailability through gastric flow. At this concentration, Piperine has been shown to increase the absorption of iron, zinc, vitamins, calcium and other therapies some by greater than 300% and is currently being studied for inclusion with certain pharmaceuticals for this purpose.

(1) Panahi Y, Ghanei M, Hajhashemi A et al: Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial. J Diet Suppl. 2014 Aug 29. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25171552

(2) Panahi Y, Badeli R, Karami GR et al: Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder. Phytother Res. 2014 Aug 4. doi: 10.1002/ptr.5211. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25091591

(3) Rahimnia AR, Panahi Y, Alishiri G et al: Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo- Controlled Trial. Drug Res (Stuttg). 2014 Jul 22. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/25050518

(4) Ajazuddin, Alexander A, Qureshi A et al: Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. Fitoterapia. 2014 Sep;97C:1-14. http://www.ncbi.nlm.nih.gov/pubmed/24862064

(5) Wightman EL, Reay JL, Haskell CF et al: Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014 Jul;112(2):203-13. http://www.ncbi.nlm.nih.gov/pubmed/24804871

(6) Feng X, Liu Y, Wang X et al: Effects of piperine on the intestinal permeability and pharmacokinetics of linarin in rats. Molecules. 2014 Apr 30;19(5):5624-33. http://www.mdpi.com/1420-3049/19/5/5624

(7) Kesarwani K1, Gupta R, Mukerjee A: Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013 Apr; 3(4):253-66. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/